Pattern of Use of Biosimilar and Originator Somatropin in Italy: A Population-Based Multiple Databases Study During the Years 2009-2014.

Front Endocrinol (Lausanne) · 2018 · PMC5859012 · PMID 29593655

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a decreasing trendno p-value reported

A decreasing trend was observed over time in center n. 1 (11.6 vs. 2.1%) and n. 6 (7.7 vs. 1.9%); instead, an increasing trend was observed in center n. 5 (5.0 vs. 7.5%), center n. 4 (4.7 vs. 11.6%), and even more in center n. 3 (5.2 vs. 16.9%).

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an increasing trendno p-value reported

The national report on medicines use in Italy reported a decreasing overall consumption of rGH in 2015, but showed an increasing trend in biosimilar rGH use, compared to the previous year (+21.5% for biosimilar rGH).

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