A prospective, randomized, comparative study of intravenous alone and combined intravenous and intraarticular administration of tranexamic acid in primary total knee replacement.

Arthroplast Today · 2018 · PMC5859204 · PMID 29560401

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a positive trendno p-value reported

This effect was noticed at POD 4, with a positive trend for less drained blood in the first 24 hours and less total blood loss in the group that received combined IV and IA administration of TXA.

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