Chromosomal breaks at FRA18C: association with reduced <i>DOK6</i> expression, altered oncogenic signaling and increased gastric cancer survival.

21 This showed highly significant enrichment of three Kyoto Encyclopedia of Genes and Genomes (KEGG) 22 signaling pathways: Ras (FDR P = 3.35 × 10 −17 ); Rap1 (RAP1 GTPase activating protein) (FDR P = 2.96 × 10 −14 ) and PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase)-Akt (AKT serine/threonine kinase) (FDR P = 7.90 × 10 −12 ) (Fig. 2e ).

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