Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.

Of the genes that were found to be upregulated in clk-1 , isp-1 and nuo-6 worms, 46%, 50% and 57%, respectively, were also upregulated in daf-2 mutants ( Fig 2A ), which represents a highly significant degree of overlap ( Table 1 ).

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