Ectopic Telomerase Expression Fails to Maintain Chondrogenic Capacity in Three-Dimensional Cultures of Clinically Relevant Cell Types.

However, interestingly there were indications, such as the sustained differential response to MM and PChM, SOX9 expression, and in particular the improvement seen by transferring OK3H from a 2D to a 3D environment, which suggested that the transduction while clearly significantly impacting upon the cells' chondrogenic potential had not completely abrogated the chondrogenic response, and future optimization of the immortalization process may produce cell lines with much greater in vitro utility.

also in 180 other papers