highly significantp=0.001
High-risk tumour depths (≥4mm) demonstrated a highly significant negative dependence on both PO 4 -SMAD2 (Table 2 , C.C −0.214; p=0.001) and PO 4 -SMAD3 (Table 2 , C.C −0.200; p=0.002) ( Supplementary Figures 7A and 8 ) histoscores, suggesting a correlation between thicker tumours and lower SMAD2/3 phosphorylation.