Barely Significant
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Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.

Oncotarget · 2018 · PMC5865689 · PMID 29581863

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highly significantp=0.001actually significant
High-risk tumour depths (≥4mm) demonstrated a highly significant negative dependence on both PO 4 -SMAD2 (Table 2 , C.C −0.214; p=0.001) and PO 4 -SMAD3 (Table 2 , C.C −0.200; p=0.002) ( Supplementary Figures 7A and 8 ) histoscores, suggesting a correlation between thicker tumours and lower SMAD2/3 phosphorylation.

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