NF‑κB is a key modulator in the signaling pathway of Borrelia burgdorferi BmpA‑induced inflammatory chemokines in murine microglia BV2 cells.

The expression of the three chemokines demonstrated an increasing trend between 12 and 48 h, except for a slight decline in CCL5 between 24 and 48 h ( Fig. 1B ). rBmpA stimulation induces an increase in NF-κB and decrease in IκB-bmRNA in BV2 cells rBmpA stimulation significantly increased CXCL2, CCL5 and CCL22 expression compared with the PBS control (P<0.05).

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