T-cell repertoires in refractory coeliac disease.

Strikingly, 80% of patients with RCD type II (4/5) progressing to an EATL had frequencies of the most common clonotype >50%, resulting in a highly significant difference if compared with any other CD group (ACD p=0.0005; CD GFD p=0.0005; RCD type I p=0.0016; Marsh I p=0.0357) as well as to controls (p=0.0010; figure 3 A).

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We detected a borderline significant association with TRBV6 and TRBV7 (p=0.045 and p=0.050, respectively, online supplementary figure S3B).

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