However, if we excluded the loops connecting membrane-spanning α-helices, it was possible to observe a potential 3-TMS structural repeat with borderline significance, RMSD = 3.57 Å over a 60 residue alignment where TMSs 3–5 align with TMSs 6–8 (See Methods and S1 Fig ).
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Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases.
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