HopLand: single-cell pseudotime recovery using continuous Hopfield network-based modeling of Waddington's epigenetic landscape.

Bioinformatics · 2017 · PMC5870541 · PMID 28881967

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a decreasing trendno p-value reported

In the landscape, the change of the network energy shows a decreasing trend along the differentiation process which confirms our premise that cell differentiation is a process with decreasing energy.

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