The second selects, within each of the 16 C/T-specific TF-TG sets, only the TFs (hereafter relevant TFs) with: (i) highly significant enrichment for their C/T (FDR ≤ 0.01) and (ii) top (50) betweenness centrality ( Koschutzki and Schreiber, 2008 ) computed by the igraph R package ( Csaridi and Nepusz, 2006 ). 2.6 Confirmatory DNA methylation analysis Based on the interpretation of the results of eegc on Sandler et al. dataset, an additional, custom, analysis was run to explore the potential epigenetic causes of the observed cell lineage conversion.
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Systemic evaluation of cellular reprogramming processes exploiting a novel R-tool: eegc.
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