Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine kinase 1 and inhibiting necroptosis.

Cell Death Dis · 2017 · PMC5870585 · PMID 29233979

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highly significantno p-value reported

Our current data reveal that hiPSCs-MSCs-derived EVs may represent a novel highly significant function to protect tissues against I/R injury.

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