Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus.

Lupus · 2018 · PMC5871021 · PMID 29050534

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highly significantno p-value reported

Moreover, the role of C4 copy numbers is substantiated by our finding of a clear and highly significant relationship between complement C4 copy numbers and C4 serum levels.

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