HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain.

FoldX-predicted energy changes, i.e., ΔΔ G values, of >1.6 kcal/mol are considered highly significant (99% confidence interval), as they correspond to twice the standard deviation of the error in FoldX and correspond to mutations that confer severely reduced structural stability, while smaller energy changes of >0.8 kcal/mol are still considered significant (1 standard deviation; 95% confidence interval) ( 52 – 55 ).

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