Evolution of echovirus 11 in a chronically infected immunodeficient patient.

Fig 6A shows that amino acid substitutions in most viral proteins were largely neutral, except for proteins 3C (protease) and 3D (RNA polymerase) (p-values 0.0366 and 0.0332), and marginally significant for 3A (p-value of 0.0910) that were under negative selective pressure.

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