The Association between Maternal Stress and Childhood Eczema: A Systematic Review.

[ 17 ] showed that when atopic dermatitis diagnosis was based on the exhibition of atopic dermatitis-associated symptoms and not the definition by dermatologists, the increased risk of the child having atopic dermatitis would become borderline significant with the experience of increased chronic stress in mothers.

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While an almost significant association between maternal chronic stress and childhood atopic dermatitis risk was observed when symptom observation was used as a strategy for atopic dermatitis ascertainment (adjusted RR: 1.5, 95% CI: 1.0–2.3, p = 0.05), such association was determined to be insignificant when the strict definition of atopic dermatitis was used (adjusted RR: 1.1, 95% CI: 0.7–1.9).

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