In addition, study-specific analyses showed that the associations between ACO and sleep-related or respiratory symptoms were highly significant in both populations, although the association was stronger in the GA 2 LEN population than in the RHINE III population for most symptoms ( Table 4 ).
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Asthma and COPD overlap (ACO) is related to a high burden of sleep disturbance and respiratory symptoms: Results from the RHINE and Swedish GA2LEN surveys.
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