Long-lived rodents reveal signatures of positive selection in genes associated with lifespan.

PLoS Genet · 2018 · PMC5884551 · PMID 29570707

Europe PMC DOI

hedged sentences

0.0017

closest p · 0.0× alpha

0.1000

boldest claim

The sentences

highly significantp = 0.0017actually significant

Moreover, 68 PSGs were both down-regulated in the long-lived naked mole-rat and up-regulated in the short-lived rat during aging ( Fig 2 ), resulting in a highly significant preference for quadrant I (down in naked mole-rat, up in rat; p = 0.0017, one-sided fisher test, quadrant I against the sum of II, III, IV).

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borderline significantp = 0.10so close (0.05 < p ≤ 0.1)

Regarding only the 68 PSGs that were down-regulated in naked mole-rat and up-regulated during rat aging (quadrant I, Fig 2 ), “cellular respiration” showed a significant (p = 2.4*10 −7 ) and “translation” a borderline significant enrichment (p = 0.10; S23 Table ).

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