Should vitamin B₁₂ status be considered in assessing risk of neural tube defects?

53 In this study, the most significant risk factors were two tightly linked rare variants (rs2336573 and rs9426) that were highly significant in a recessive model and were not detected in nearly 1000 controls but were present in eight and seven cases with spina bifida, respectively. 53 The variants conferred an approximate sixfold risk to cases; 53 however, because of low frequency, it must be said that they are unlikely to contribute greatly to the general risk of NTD in the population.

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