Association of EGLN1 genetic polymorphisms with SpO₂ responses to acute hypobaric hypoxia in a Japanese cohort.

Through the GLM analysis, the rs12097901 genotype showed a significant association with SpO 2 latency ( P = 0.006) in the additive model, whereas the rs2790859 genotype was related to the latency with borderline significance ( P = 0.014) (Table 2 and Fig. 2 ).

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The difference in SpO 2 values at 0 min was statistically significant ( P = 0.008), and the interaction between time and genotype was borderline significant ( F (3, 132) = 3.6, P = 0.015): the mean SpO 2 value at 90 min in individuals with HL alleles was higher than that in individuals with non-HL allele.

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