Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease.

8 11 20–24 Notably, not only did we observe higher basal expression of MAIT cell cytotoxicity markers in ALD than controls, but among ALD patients we also observed a small trend for stronger bacteria-induced MAIT cell cytotoxicity in those with increased plasma markers of bacterial translocation.

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In few patients with SAH, we observed a possible trend for a correlation between E. coli -stimulated cytotoxic potential of MAIT cells and increased plasma markers of bacterial translocation (CD107a induction vs D-lactate in SAH: r=0.985, p=0.015).

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