Pathological mechanisms underlying single large-scale mitochondrial DNA deletions.

15 , 16 , 17 , 18 , 19 Whereas a highly significant, 20 significant, 15 , 16 , 21 , 22 weak, 18 , 23 or no 24 correlation has been reported between the percentage of COX‐deficient fibers and the degree of mtDNA heteroplasmy, most studies found no correlation between the biochemical defects and the nature of the deletion (the number of protein‐encodi

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