Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.

Comparison of the transcription changes induced by LSD1 inhibition with those observed during phorbol-ester-mediated terminal differentiation of THP1 AML cells into macrophages ( Suzuki et al., 2009 ) revealed a highly significant overlap ( Figure 1 F).

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However, LSD1 also interacts with multiple transcription factors ( Lynch et al., 2012 ), raising the possibility that other mechanisms may be significant.

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