Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent alternative promoter usage during mouse early embryogenesis.

Thus, apart from constitutive splicing, variant presence of splicing factors might account for the different AS efficiencies and patterns across the three samples and therefore the distinct developmental consequences. When performing GO analysis of the 1,279 alternatively spliced genes, we observed a highly significant enrichment of genes associated with RNA processing and/or splicing ( Fig. 3 B).

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