Clock-dependent chromatin topology modulates circadian transcription and behavior.

While the differential signal covered the entire Cry1 locus , the largest difference was localized—peaking 26 kb downstream from the TSS in the first Cry1 intron—and highly significant ( P < 5.5 × 10 −17 at the peak) ( Fig. 1 B, bottom tracks, vertical dotted line at the left).

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