Conventional Versus Giant Basal Cell Carcinoma, a Review of 57 Cases: Histologic Differences Contributing to Excessive Growth.

suggested that differing neuromodulator expression could account for size difference, but found that the expression of adrenocorticotropic hormone (ACTH), serotonin, β-endorphin, and met-enkephalin was similar in GBCC and conventional BCC.[ 13 ] Other authors suggest that a weakened immune system plays an important role in tumorigenesis,[ 1 ] and at least one study has found single-nucleotide polymorphisms in genes important in immune regulation in patients developing BCC (of any type, not specifically GBCC).[ 22 ] Our study showed a nonsignificant trend toward more host inflammation in GBCC compared to conventional BCC; this finding would suggest that patients with GBCC can mount a host response, although our study was not designed to assess the functional capacity of the infiltrate.

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