25 Others propose a gold standard of 30 minutes, although some evidence exists that even with such a small delay, effects on tissues such as gene expression may be significant. 49 , 50 Concurrent measurement of the reduction of housekeeping gene expression levels may provide information regarding the levels of RNA quality degradation. 51 The fixation process has great influence on RNA quality because it causes strand breakage and cross-linking with other biomolecules.
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The role of the pathology department in the preanalytical phase of molecular analyses.
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