Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.

Consistent with anti-Gag (particularly p24) CD8+ T-cell responses as key determinants of HIV control 61 , 64 – 67 , we previously identified two highly significant B*39 : 02 -associated polymorphisms in Gag (at codons 315 and 319, both in p24) and three in Pol (at codons 70 and 79 in protease, and 322 in reverse transcriptase) 40 , suggesting strong and reproducible targeting of these regions by B*39 : 02 -restricted T-cell responses as possible determinants of B*39 : 02 -mediated HIV control, where such effects remain detectable into chronic HIV-1 infection.

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