What is the evidence for a role for diet and nutrition in osteoarthritis?

In obese participants undertaking a weight-control intervention, weight reduction reduced peak knee load and pain [ 32 ], and provided symptomatic relief, irrespective of structural damage [ 36 ]. Datasets from the Osteoarthritis Initiative and the Multicentre Osteoarthritis Study demonstrate a highly significant ( P < 0.003) dose–response relationship between weight change and improvement in WOMAC pain and function [ 37 ].

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