highly significantP =0.0001
However, there was a 0.1‐mg/dL increase in creatinine between the screening visit and day −1 to 1.2 mg/dL (1.0–1.6 mg/dL) in the CR group, and this incremental change was highly significant ( P =0.0001) compared with the control group, in which serum creatinine was not altered (1.1 mg/dL [0.9–1.3 mg/dL]).