Six 91 , 75 , 67 , 79 , 83 - 84 showed that the baseline VEGF level expressed had a significant decrease after treatment; of the other three, one 70 was about lymph node metastasis diagnosis, another one 89 showed an increasing trend of the VEGF level during treatment, and the last one 76 showed no change during therapy, while the VEGF baseline level was associated with response to therapy 76 , 89 .
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Evaluation of Detection Methods and Values of Circulating Vascular Endothelial Growth Factor in Lung Cancer.
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Two of the multicenter trials 86 , 89 found that the plasma level of VEGFR-2 expressed a decreasing trend during treatment, and one 86 showed the baseline VEGFR-2 level correlated with the response to treatment, while the other did not 89 .