Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.

Biochem Pharmacol · 2018 · PMC5908784 · PMID 29454620

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did not achieve significanceno p-value reported

Within ECL2, efficacy was attenuated for all peptides at the Y299A mutant and enhanced at the H296A and I300A mutants, albeit that the H296A and I300A mutants did not achieve significance for hCT or pCT, respectively ( Fig. 11 C, Fig. 12 C, Table 6 ).

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