MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers.

Oncogenesis · 2018 · PMC5908790 · PMID 29674704

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highly significantno p-value reported

Analysis of the most robust (log 2 FC > 2 or < -2) gene expression changes unique to the combination revealed highly significant overlap between down-regulated genes and MSigDB signatures associated with mitosis (Supplemental Tables S5 - S6 ) at both time points, with a more significant overlap occurring at 96 h.

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