highly significantP ≤ 0.001
Highly significant ( P ≤ 0.001) decrease of SAM and SAH was also observed in subjects with ASD.[ 114 ] These observations were supported by detailed analysis of metabolic and nutritional status of 55 children with ASD ages 5–16 years compared with nonsibling, neurotypical controls ( n = 44).[ 3 ] Fluoride can contribute to disturbances in GSH homeostasis because it enters the cascade and attaches to the SAH.