Tumor budding is an independent prognostic marker in early stage oral squamous cell carcinoma: With special reference to the mode of invasion and worst pattern of invasion.

PLoS One · 2018 · PMC5909609 · PMID 29672550

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A final stepwise model for Cox multivariate analysis identified the intensity of tumor budding at the invasive front of the tumor as the most highly significant and independent prognostic marker in patients with cT1,2N0M0 OSCC (HR = 2.18, 95% CI = 1.49–3.20, p<0.01; S5 Table ).

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