Concentration-related metabolic rate and behavioral thermoregulatory adaptations to serial administrations of nitrous oxide in rats.

Mixed model analysis of core temperature data averaged over the first 90 min of administration indicated highly significant effects of session and the concentration by session interaction (p<0.0001), but the main effect of concentration was non-significant (p = 0.20), consistent with the core temperature sign-reversals from hypothermia to hyperthermia in the three highest concentration groups (particularly evident in Fig 2 ).

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