Wnt Signalling Drives Context-Dependent Differentiation or Proliferation in Neuroblastoma.

Notably, although we identified WMG-2 in the predominantly MNA cluster 3, Kaplan-Meier analysis of low-risk tumours in the SEQC dataset (n=322) with WMG-2 demonstrated a highly significant association of low WMG-2 with poor survival (p=8.2 x 10 -9 ) ( Figure 5 D , right).

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Whilst the differentiating effects of Wnt ligands may be significant for potential differentiation therapies, the proliferative effect seen with SK-N-AS cells underlines the need for further delineation of the genotypes and transcriptional/signalling contexts determining Wnt responses.

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