RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors.

Nat Commun · 2018 · PMC5920046 · PMID 29700298

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an increasing trendno p-value reported

In fact, at 6 weeks post-administration of the higher AAV dose, Pcsk9 transcript levels were indistinguishable from non-treated controls and serum protein levels displayed an increasing trend relative to earlier time points.

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