The therapeutic effect of miR-125b is enhanced by the prostaglandin endoperoxide synthase 2/cyclooxygenase 2 blockade and hampers ETS1 in the context of the microenvironment of bone metastasis.

Cell Death Dis · 2018 · PMC5920088 · PMID 29700305

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highly significantno p-value reported

Importantly, the adverse effect of miR-125b mimic plus NS-398 on metastatic growth started at 4 days from 1833/TGL-cell injection and became highly significant at 9 days, leading to suppose that the hampering of colonization was caused by molecular and cellular modifications at early stages after bone engraftment of DTC.

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