We thus used the following formula to rank all genes according to their suitability for creating stroma gene-sets: 1 p score = p unbal p bal 2 The squared term in the denominator was included to reflect that more pronounced differences in p-values are necessary for highly significant genes to be regarded as stroma genes.
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Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized.
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