Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis.

As a result, we observed a highly significant overlap among genes modulated (P-value < 0.05, fold change > 2 and detectable expression) in tumor cells by exposure to N- or T-MSCs ( Fig. 6 B and Table S2), consistent with the observation that tumors contribute to N-MSC acquisition of a T-MSC phenotype.

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