Barely Significant
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A pilot study of the modulation of sirtuins on arylamine <i>N</i>-acetyltransferase 1 and 2 enzymatic activity.

Acta Pharm Sin B · 2018 · PMC5926248 · PMID 29719779

Europe PMCDOI
1
hedged sentence
0.0050
closest p · 0.1× alpha
0.0050
boldest claim

The sentences

highly significantP <0.005actually significant
n; SMZ, sulfamethazine; SREBP1a, sterol regulatory element-binding protein 1a; SREBP2, sterol regulatory element-binding protein 2 KEY WORDS: Arylamine N -acetyltransferase, NAT, Sirtuins, Peripheral blood mononuclear cells, Nicotinamide, Resveratrol Graphical abstract The present study exhibited a highly significant effect ( P <0.005) on NAT2 activity in peripheral blood mononuclear cells once deacetylation function of sirtuins is inhibited by nicotinamide (NAM) generating high levels of Ac-INH which suggests a post-translational regulatory mechanism. status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2017 Sep 11; Revised 2017 Nov 15; Accepted 2017 Nov 17; Issue date 2018 Mar. 1.

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