Increased frequencies of gene and chromosome mutations after X-irradiation in mouse embryonal carcinoma cells transfected with the bcl-2 gene.

However, when the cells were irra- diated, the slopes of the dose response for S2 and S3 cells were about twice that of F9 cells, indicating that MN fre- quencies after X-irradiation were consistently higher in cells overexpressing the bcl-2 gene and the differences were highly significant at the dose point of 4 Gy (P= 0.0002-0.002).

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