Effects of three-month oral supplementation of beta-carotene and vitamin C on serum concentrations of carotenoids and vitamins in middle-aged subjects: a pilot study for a randomized controlled trial to prevent gastric cancer in high-risk Japanese population.

m response, both for the level of increase and the time needed to reach a steady state, observed in this study was comparable to those in the previous studies. Compared to -carotene, the increase in serum ascorbic acid afforded by high-dose vitamin C supplementation was low, 88-94%, although it was highly significant.

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