DNA ladder formation, an indicator of inter- nucleosomal DNA cleavage, began to be detected on agarose gel electrophoresis 8 h after incubation, followed by an increasing trend at 16 h (Fig. 1B).
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Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression.
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