Chemopreventive effects of a flavonoid antioxidant silymarin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice.

In particular, exposure to silymarin resulted in a highly significant pro- tection against benzoyl peroxide (BPO)-induced tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated skin carcinogenesis in SENCAR mice.20) This agent is also reported to inhibit cell proliferation, cell growth, and cell cycle progression in various types of cancer.21-24) In the present study, chemopreventive effects of sily- marin were examined by exposure during the initiation and postinitiation stages on N-butyl-N-(4-hydroxybutyl)- nitrosamine (OH-BBN)-induced urinary-bladder carcino- genesis in mice.

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