Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages.

In particular at the late time point at 24 h, Mtb down-regulated genes were highly significant enrichment for ontology terms such as “nucleosome assembly” (GO: 0006334), “chromatin assembly” (GO: 0031497), “protein–DNA complex assembly” (GO: 0065004), “DNA packaging” (GO: 0006323), which may imply that possible dis-regulation of basic cellular functions may occur in macrophages around 24 h post Mtb-infection.

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