While the gene expression of HCN4 in NPRA heterozygous ventricles (+/−) revealed a decreasing trend compared to that in WT ventricles (+/+), HCN4 expression levels significantly decreased in homozygous ventricles (−/−) when compared to those in WT samples (2.6-fold reduction Vs.
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Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system.
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