Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-<i>Mycobacterium tuberculosis</i> Strains.

In particular, mutation in the rpoB gene at 531 codon (serine to leucine) is highly significant as it confers cross-resistance to rifabutin (Mboowa et al., 2014 ; Thirumurugan et al., 2015 ; Aye et al., 2016 ). whereas mutations at codons 516, 518, 526, and 529 are associated with low-level resistance to RIF and conserved susceptibility to other rifamycins, e.g., rifabutin or rifalazil (Cavusoglu et al., 2004 ; Tan et al., 2012 ).

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