A single institution experience for the management of recurrent pleural effusions with tunneled pleural catheter and its evolution.

Nevertheless, this burden does not appear to have an adverse effect on overall quality of life in the TIME-2 trial, which noted similar improvement in both arms with a nonsignificant trend favoring IPC. 15 The TIME-2 randomized trial of IPC versus talc pleurodesis also did not find a difference in the primary outcome measure of dyspnea improvement at 42 days on a visual analog scale, although improved symptoms became significant at the 6 months’ time point in favor of the IPC group. 15 The commonest protocol (TPC in the endoscopy suite without sclerosant instillation with liberal drainage) had a mean indwelling time of 57 days with a range of 23–372 days.

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